منابع مشابه
Intranasal delivery of morphine.
Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over ...
متن کاملIntranasal delivery of morphine may offer better effects.
Researchers from Memorial SloanKettering Cancer Center have created a formula that older, long-term smokers and ex-smokers can use to calculate their risk for developing lung cancer. Lung cancer risk is dependent on each individual’s smoking pattern and history. For example, when the formula is used to compute risk, a 52-year-old woman who smoked a pack of cigarettes per day for 25 years and qu...
متن کاملIntranasal delivery of cells to the brain.
The safety and efficacy of cell-based therapies for neurodegenerative diseases depends on the mode of cell administration. We hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid (CSF). This would minimize or eliminate the di...
متن کاملRecent trends in drug delivery systems: intranasal drug delivery.
Nasal route of drug delivery is commonly known for treatment of local ailments like-cold, cough, rhinitis etc. Recently, efforts have been made to deliver various drugs, specially peptides and proteins, through nasal route for systemic use; utilizing the principles and concepts of rate controlled drug delivery and various polymers and absorption promoters. Considering the large number of proble...
متن کاملUse of N-trimethyl chitosan for intranasal delivery of DNA encoding M2e-HSP70c in mice
BACKGROUND: Influenza outbreak has become a great lifethreateningdisease in the world. Nasal vaccines can inducesystemic IgG and mucosal IgA antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. Mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. Therefore, nas...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2002
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.301.1.391